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progesterone capsules 200 mg

Progesterone IR

(Commercial Product) Capsule

100 mg  |  200 mg

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Disclaimer: Images are for reference only; actual products may vary.

Product Overview

Progesterone IR Description1-3

Micronized progesterone is a bioidentical version of the naturally occurring hormone progesterone, processed into micron-sized particles to improve oral absorption. It is utilized in multiple clinical applications within women’s health, including hormone replacement therapy (HRT), treatment of luteal phase deficiencies, menstrual irregularities, infertility management, and prevention of endometrial hyperplasia in postmenopausal women undergoing estrogen therapy. Progesterone can also be compounded into oral capsules for administration by mouth.

Mechanism of Action 1-3

Progesterone is a steroid hormone primarily secreted by the corpus luteum and, during pregnancy, the placenta, it binds PR-A & PR-B receptors and the primary actions in women include:

  • Endometrial transformation: Converts the endometrium from a proliferative to a secretory state, supporting implantation and pregnancy.
  • Regulation of gonadotropin secretion: Via negative feedback on the hypothalamic-pituitary axis.
  • Stabilization of the endometrium helps to prevent irregular bleeding in women receiving estrogen therapy.
  • CNS effects: Modulates mood, sleep, and neuroprotective pathways through GABA-A receptor modulation.

Common1-3

  • Drowsiness or sedation
  • Breast tenderness
  • Headache
  • Bloating
  • Mood changes
  • Irregular bleeding or spotting
  • Dizziness

Contraindications1-3

Micronized progesterone should not be used in individuals with:

  • Known or suspected pregnancy (when used outside pregnancy-supporting protocols)
  • Undiagnosed abnormal menstrual bleeding
  • Known, suspected, or history of breast cancer
  • Active or history of thromboembolic disorders (stroke, DVT, heart attack etc…)
  • Liver dysfunction or disease
  • Hypersensitivity to progesterone or any formulation components

Precautions1-3

  • Use in patients with a history of depression should be monitored closely.
  • Caution in cardiovascular disease, migraine, or seizure disorders.
  • In women with a uterus, progesterone is required alongside estrogen to prevent endometrial hyperplasia.
  • Store at controlled room temperature (20°C to 25°C / 68°F to 77°F)
  • Protect from moisture and light
  • Keep in a tightly closed container
  1. FDA Label for Prometrium® (micronized progesterone); accessed July 2025 through: https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/019781s013lbl.pdf
  2. Cynthia A. Stuenkel, Susan R. Davis, Anne Gompel, Mary Ann Lumsden, M. Hassan Murad, JoAnn V. Pinkerton, Richard J. Santen, Treatment of Symptoms of the Menopause: An Endocrine Society Clinical Practice Guideline, The Journal of Clinical Endocrinology & Metabolism, Volume 100, Issue 11, 1 November 2015, Pages 3975–4011, accessed July 2025 through: https://doi.org/10.1210/jc.2015-2236
  3. Clinical Pharmacology Progesterone clinical monograph accessed July 2025 through: https://www.clinicalkey.com/pharmacology/monograph/515?n=Progesterone

WPPL operates as a 503A compounding pharmacy and prepares individualized prescription medications pursuant to provider direction. Compounded preparations are not reviewed, tested, or approved by the FDA.

This listing also includes commercially manufactured products for convenience; these items are not compounded by our pharmacy and are sold as provided by their manufacturers. Actual products in stock at time of dispensing may vary due to supply chain variability. Any statements regarding non-compounded products are manufacturer-supplied, have not been evaluated by the FDA, and are not intended to diagnose, treat, cure, or prevent any disease. WPPL does not verify or endorse any therapeutic claims made by manufacturers. Please refer to original labeling for complete product information.

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