(HLMT-VIT E for Women) Solution
1% / 0.05% / 6% / 0.01% / 1%
Product Overview
This topical formulation for women combines hydrocortisone, latanoprost, minoxidil, tretinoin, and vitamin E into a solution to promote hair regrowth, reduce inflammation, and nourish the scalp. Each ingredient has a unique mechanism of action to support development and growth of hair. This formulation is designed to enhance follicle activity and protect against oxidative stress, it supports healthier, fuller hair with consistent use.
Hydrocortisone1,2
Hydrocortisone is a synthetic version of cortisol, a hormone produced by the adrenal glands, and possesses both glucocorticoid and mineralocorticoid activity. When used topically, hydrocortisone exhibits anti-inflammatory, antipruritic, anti-mitotic, and immunosuppressive effects. Among topical corticosteroids, hydrocortisone is considered a low-potency option.
Latanoprost3-7
Latanoprost acts as an analogue of prostaglandin F2α (PGF2α). It is used in glaucoma management and has also been observed to influence hair growth. Findings have noted its effects in areas such as androgenetic alopecia and eyelash or eyebrow hypotrichosis. Interest in its role in hair growth originally stemmed from reports of enhanced eyelash growth in individuals using it for glaucoma.
Minoxidil8-10
Topical minoxidil is a vasodilatory compound originally developed as an oral antihypertensive agent. It was found to stimulate hair growth (from the observation of hypertrichosis (excessive, abnormal hair growth) in patients taking oral minoxidil) and was subsequently FDA approved for androgenetic alopecia (male and female pattern hair loss).
Tretinoin11-14
Tretinoin, a naturally occurring derivative of vitamin A, is also known as all-trans-retinoic acid. Retinoids may participate in regulating cell reproduction, proliferation, and differentiation. When used alongside minoxidil, tretinoin has been associated with increased expression of certain markers linked to hair growth (such as Erk, Akt, Bcl-2, and Bax).
Vitamin E15
Vitamin E (tocopherol) is a fat-soluble antioxidant that contributes to protecting cell membranes. Because the body does not synthesize vitamin E, it must be obtained externally. It may limit the formation of reactive oxygen species and help maintain collagen and glycosaminoglycan synthesis in the skin. Vitamin E has been studied in connection with several dermatologic conditions, including atopic dermatitis, epidermolysis bullosa, psoriasis, wound care, melasma, scleroderma, and acne vulgaris.
Hydrocortisone1,2
The anti-inflammatory effects of topical hydrocortisone may occur through vasoconstriction. The vasoconstriction minimizes inflammatory mediators delivered to the inflamed area. Topical hydrocortisone may also inhibit the release of phospholipase A2, which reduces prostaglandins and leukotriene. Lastly, topical hydrocortisone inhibits DNA and transcription factors related to inflammation. It does this by increasing the expression of anti-inflammatory genes and indirectly inhibit inflammatory transcription factors, such as NF-kB, to decrease the expression of pro-inflammatory genes.
Topical hydrocortisone also has an anti-mitotic effect by decreasing epidermal mitosis mediated through an increase in lipocortin, an endogenous glucocorticoid-regulated protein.
Topical hydrocortisone also inhibits humoral factors in the inflammatory response by suppressing immune cells from maturing, differentiating and proliferating.
Latanoprost3-7
Latanoprost binds to the prostaglandin F2α receptor on hair follicle dermal papilla cells, influencing the hair growth cycle as follows:
Increases the duration of anagen, which may result in longer and thicker hair shafts.
May enhance pigmentation in vellus hairs, which may make them appear darker and more terminal-like.
Some studies suggest latanoprost may increase the number of follicles actively producing hair, particularly in the eyelash and eyebrow regions, and potentially the scalp.
Minoxidil8-10
The drug has many mechanisms in supporting hair growth:
Tretinoin11-14
Tretinoin may have several mechanisms to facilitate hair growth including the following:
Vitamin E15
Hydrocortisone1,2
Common
Latanoprost6,7
Common
Minoxidil8-10
Common
Topical minoxidil is generally well tolerated but may cause local effects:
Tretinoin11
Common
Contraindications 1,2,6,7,8-11
Precautions 1,2,6,7,8-11
Store at room temperatures between (59-86°F). Protect from light and keep the container tightly closed. Keep out of reach of children and pets.
WPPL operates as a 503A compounding pharmacy and prepares individualized prescription medications pursuant to provider direction. Compounded preparations are not reviewed, tested, or approved by the FDA.
This listing also includes commercially manufactured products for convenience; these items are not compounded by our pharmacy and are sold as provided by their manufacturers. Any statements regarding non-compounded products are manufacturer-supplied, have not been evaluated by the FDA, and are not intended to diagnose, treat, cure, or prevent any disease. WPPL does not verify or endorse any therapeutic claims made by manufacturers. Please refer to original labeling for complete product information.
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Providers: Let’s Partner for Better Patient Care
If you are a physician, clinic, or practice seeking a dependable Compounding Pharmacy partner, WP Pharma Labs is here to help. With dedicated account setup, streamlined ordering and responsive service, we support your therapeutic goals with specialized compounds designed for your patients.
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