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Enclomiphene Citrate

Enclomiphene Citrate

Capsules

5 mg  |  12.5 mg |  25 mg  |  50 mg

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Disclaimer: Images are for reference only; actual products may vary.

Product Overview

Enclomiphene Citrate Description1-4

Enclomiphene citrate is a nonsteroidal selective estrogen receptor modulator (SERM) derived from clomiphene citrate. While clomiphene is a racemic mixture containing both enclomiphene (the trans-isomer) and zuclomiphene (the cis-isomer), enclomiphene consists solely of the trans-isomer. Due to its ability to stimulate endogenous testosterone production, enclomiphene is being considered for the management of secondary hypogonadism in men, particularly in cases where preservation of fertility is desired.

Mechanism of Action1-4

Enclomiphene works by antagonizing estrogen receptors in the hypothalamus, thereby reducing negative feedback inhibition on the hypothalamic-pituitary-gonadal (HPG) axis. This leads to:

  • Increased GnRH secretion (from the hypothalamus)
  • Stimulation of LH and FSH release (from the anterior pituitary)
  • Subsequent endogenous testosterone production and spermatogenesis (via Leydig and Sertoli cell activation)

Common1-4

Most side effects are mild and transient, but may include:

  • Headache
  • Nausea
  • Mood changes or irritability
  • Gynecomastia or breast tenderness
  • Acne or oily skin
  • Elevated hematocrit or hemoglobin (monitor if long-term use)

Contraindications1-4

  • Known hypersensitivity to enclomiphene or other SERMs
  • Active or previous history of hormone-sensitive cancers (e.g., prostate or breast cancer)
  • Severe liver disease
  • Uncontrolled thromboembolic disorders

Precautions1-4

  • Regular monitoring of serum testosterone, estradiol, LH, and FSH is advised
  • Assess sperm parameters in men using for fertility support
  • Use caution in men with cardiovascular disease or sleep apnea
  • Enclomiphene may increase testosterone beyond physiologic levels if overused
  • Discontinue if vision changes or thromboembolic symptoms occur
  • Store at controlled room temperature (20°C to 25°C / 68°F to 77°F)
  • Protect from moisture and light
  • Keep in a tightly closed container
  1. Kassab J, Saffati G, Lipshultz L, Khera M. Safety and Efficacy of Enclomiphene Compared to Clomiphene for Hypogonadal Men. J Sex Med. 2024;21(Supplement_1):qdae001.090. https://doi.org/10.1093/jsxmed/qdae001.090
  2. Rodriguez KM, Pastuszak AW, Lipshultz LI. Enclomiphene citrate for the treatment of secondary male hypogonadism. Expert Opin Pharmacother. 2016;17(11):1561–7. doi:10.1080/14656566.2016.1204294
  3. Thomas J, et al. Efficacy of Clomiphene Citrate Versus Enclomiphene Citrate for Male Infertility Treatment: A Retrospective Study. Cureus. 2023;15(7):e41476. doi:10.7759/cureus.41476
  4. Wiehle R, et al. Testosterone Restoration by Enclomiphene Citrate in Men with Secondary Hypogonadism: Pharmacodynamics and Pharmacokinetics. BJU Int. 2013;112(8):1188–1200. doi:10.1111/bju.12363

WPPL operates as a 503A compounding pharmacy and prepares individualized prescription medications pursuant to provider direction. Compounded preparations are not reviewed, tested, or approved by the FDA.

This listing also includes commercially manufactured products for convenience; these items are not compounded by our pharmacy and are sold as provided by their manufacturers. Actual products in stock at time of dispensing may vary due to supply chain variability. Any statements regarding non-compounded products are manufacturer-supplied, have not been evaluated by the FDA, and are not intended to diagnose, treat, cure, or prevent any disease. WPPL does not verify or endorse any therapeutic claims made by manufacturers. Please refer to original labeling for complete product information.

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