Latanoprost (LatanoSTIM) / Minoxidil – Hair Serum

0.06% / 2.2%

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Disclaimer: Images are for reference only; actual products may vary.

Product Overview

The drugs listed below have been combined into a topical formulation for the management of hair loss.

Latanoprost Description1-5

Latanoprost is a prostaglandin F2α (PGF2α) analog that is primarily indicated for the management of open-angle glaucoma and ocular hypertension. Evidence indicates that the drug is associated with hair growth, particularly in cases of androgenetic alopecia (AGA) and eyelash or eyebrow hypotrichosis. Its association with hair regrowth was initially observed as an adverse effect involving increased eyelash growth in patients treated for glaucoma.

MinoxidilDescription6-8

Topical minoxidil is a vasodilatory compound originally developed as an oral antihypertensive agent. It was found to stimulate hair growth (from the observation of hypertrichosis (excessive, abnormal hair growth) in patients taking oral minoxidil) and was subsequently FDA approved for androgenetic alopecia (male and female pattern hair loss).

Latanoprost1-5

Latanoprost binds to the prostaglandin F2α receptor on hair follicle dermal papilla cells, influencing the hair growth cycle as follows:

  1. Prolongation of Anagen Phase (Growth Phase):

Increases the duration of anagen, which may result in longer and thicker hair shafts.

  1. Stimulation of Melanogenesis:

May enhance pigmentation in vellus hairs, which may make them appear darker and more terminal-like.

  1. Increased Follicular Density:

Some studies suggest latanoprost may increase the number of follicles actively producing hair, particularly in the eyelash and eyebrow regions, and potentially the scalp.

 

Minoxidil6-8

The drug has many mechanisms in supporting hair growth:

  • Potassium channel opening: Minoxidil is a K⁺-ATP channel opener, resulting in vasodilation and enhanced blood flow to hair follicles.
  • Prolongation of the hair cycle: It extends the growth phase of the hair cycle, leading to increased follicle size and more robust hair shafts.
  • Activation of prostaglandins: May indirectly affect prostaglandin-mediated signaling to stimulate hair follicle activity.
  • Upregulation of vascular endothelial growth factor (VEGF): Promotes angiogenesis in dermal papillae, improving follicular nourishment.

Latanoprost3-5

Common

  • Local irritation (itching, burning, erythema)
  • Hyperpigmentation of skin (especially around eyelids or eyebrows)
  • Increased pigmentation of treated hair
  • Eyelid darkening (rare with scalp use)
  • Unwanted hair growth if medication spreads to unintended areas
  • Eye irritation (if it migrates to eye area)

 

Minoxidil6-8

Common

Topical minoxidil is generally well tolerated but may cause local effects:

Local side effects (most common):

  • Scalp irritation, dryness, flaking
  • Erythema or contact dermatitis (more common with propylene glycol-containing formulations)
  • Pruritus or burning sensation
  • Unwanted facial hair growth (esp. in women or if solution drips onto other areas)

Latanoprost1-5

Contraindications:

  • Known hypersensitivity to latanoprost or prostaglandin analogs
  • Active ocular conditions if near eyes (without ophthalmologic approval)
  • History of herpetic keratitis (due to prostaglandin-induced reactivation risk)

Precautions:

  • Avoid application near the eyes unless specifically prescribed
  • Use gloves or applicator to prevent unintended hair growth on fingers/hands
  • Avoid contact with mucous membranes
  • Patients with a history of uveitis, macular edema, or intraocular surgery should be monitored if periorbital application is required

 

Minoxidil5-8

Contraindications:

  • Known hypersensitivity to minoxidil or excipients (e.g., propylene glycol, alcohol)
  • Discontinuation advised if signs of hypersensitivity or severe irritation occur

Precautions:

  • Avoid use on broken or inflamed skin to minimize systemic absorption
  • Not for use in individuals under 18 years unless directed by a physician
  • Caution in patients with cardiovascular disease (though systemic absorption is typically minimal with proper use)
  • Avoid ocular contact — rinse thoroughly if accidental exposure occurs
  • Should not be used during pregnancy or lactation unless clinically indicated and under supervision

Store in a cool, dry place, away from direct light and heat; Room temperature (20°C–25°C / 68°F–77°F) is ideal .

  1. Johnstone, M. A. (1997). Hypertrichosis and increased pigmentation of eyelashes and adjacent hair in latanoprost therapy. American Journal of Ophthalmology, 120(7), 999–1001.
  2. Blume-Peytavi, U., et al. (2012). Latanoprost stimulates human scalp hair growth in vivo. Journal of the American Academy of Dermatology, 66(5), 807–814.
  3. Kwon, O. S., et al. (2007). Prostaglandin analogs as a potential treatment for hair loss: Latanoprost and bimatoprost in the management of alopecia. International Journal of Dermatology, 46(9), 1044–1048.
  4. Clinical Pharmacology. Elsevier. Latanoprost Monograph. Accessed June 2025
  5. FDA Drug Label: Xalatan (latanoprost ophthalmic solution) https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=a98595b3-9f47-48e0-b18d-550a2095f264… Revised May 2023. Accessed June 15, 2025
  6. Clinical Pharmacology [Internet].: Elsevier; accessed May 2025; Minoxidil topical monograph. Available from: ClinicalKey; https://www.clinicalkey.com/pharmacology/monograph/408?n=Minoxidil
  7. Rogaine® (minoxidil topical solution) package insert. Johnson & Johnson Consumer Inc. https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=12fd18f0-859c-7b9a-e063-6394a90addbf… Revised March 2024. Accessed June 16, 2025
  8. Goren A, Naccarato T. Minoxidil in the treatment of androgenetic alopecia. Dermatol Ther. 2018 Sep;31(5):e12686.

WPPL operates as a 503A compounding pharmacy and prepares individualized prescription medications pursuant to provider direction. Compounded preparations are not reviewed, tested, or approved by the FDA.

This listing also includes commercially manufactured products for convenience; these items are not compounded by our pharmacy and are sold as provided by their manufacturers. Actual products in stock at time of dispensing may vary due to supply chain variability. Any statements regarding non-compounded products are manufacturer-supplied, have not been evaluated by the FDA, and are not intended to diagnose, treat, cure, or prevent any disease. WPPL does not verify or endorse any therapeutic claims made by manufacturers. Please refer to original labeling for complete product information.

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