Facial Cream
5% / 1% / 0.1% / 2%
Product Overview
Ascorbic Acid / Coenzyme Q10 / Hyaluronic Acid / Lipoic Acid is a compounded topical formulation intended to provide hydration, protection, and support for improved skin tone and elasticity, including enhancement of the visible signs of skin aging.
Ascorbic Acid1-5
Ascorbic acid, also known as vitamin C, is a water-soluble vitamin with antioxidant properties and serves as an essential cofactor in collagen synthesis, carnitine and catecholamine metabolism, and dietary iron absorption. It is an important component in maintaining healthy skin integrity. In addition to its antioxidant effects on the skin, ascorbic acid exhibits anti-inflammatory activity, functions as a depigmenting agent, and supports collagen formation. Deficiency of ascorbic acid is associated with skin aging; therefore, topical supplementation is considered one approach used in skin anti-aging strategies.
Ascorbic acid is not synthesized by the body and must be obtained through diet or supplementation. Dietary sources include citrus fruits, berries, tomatoes, potatoes, and green leafy vegetables.
Coenzyme Q10 (CoQ10)6-8
Coenzyme Q10 (CoQ10) is a lipophilic compound naturally present in the body and plays a primary role in cellular energy metabolism through the mitochondrial electron transport chain. It also acts as an antioxidant by reducing free radicals. This antioxidant activity and involvement in mitochondrial function may help decrease visible signs of skin aging and support the regeneration of skin elasticity. CoQ10 levels decline with age, resulting in reduced protection against reactive oxygen species.
The combination of tretinoin and CoQ10 supports skin turnover and enhances antioxidant protection, contributing to improved skin integrity.
Hyaluronic Acid9,10
Hyaluronic acid is a glycosaminoglycan that plays an important role in skin health. It helps maintain hydration, elasticity, and overall skin integrity and is also involved in wound healing. With aging, hyaluronic acid production decreases, which can result in drier and less elastic skin.
Lipoic Acid11,12
Lipoic acid, also known as alpha-lipoic acid, may act as an antioxidant and anti-inflammatory agent for the skin. It is thought to help reduce the effects associated with skin aging and photodamaged skin.
Ascorbic Acid1-5
Ascorbic acid functions in the aqueous compartments of the cell. As an antioxidant, ascorbic acid neutralizes free radicals by donating electrons to prevent oxidative stress. Reactive oxygen species are formed when skin is exposed to ultraviolet light forming superoxide ions, peroxide and singlet oxygen species. Ascorbic acid facilitates collagen development. It plays an important role in the maturation of collagen. It is a critical co-factor for prolyl hydroxylase and lysl hydroxylase. The level of ascorbic acid in the skin is directly tied to the structural integrity of dermal collagen. As a depigmenting agent, ascorbic acid interacts with copper ions at the tyrosinaseactive site and inhibits action of the enzyme tyrosinase, thereby minimizing the melanin formation. Ascorbic acid interferes with NFkB activity and thus decreases the activity of a number of proinflammatory cytokines such as TNFalfa, IL1, IL6 and IL8.
CoenzymeQ106-8
CoenzymeQ10 has a critical role as a cofactor for mitochondrial enzyme pathways within cells. Impairments in mitochondrial function disrupt cellular adenosine triphosphate (ATP) production and thereby inhibit the fuel for cellular repair mechanisms and function. Reactive oxygen species accumulate, which in turn can damage mitochondria, cellular membranes, and mitochondrial DNA, accelerating skin aging in a negative feedback loop. Coenzyme Q helps to facilitate mitochondrial activity and maintain energy. CoQ10 inhibits the ability of free radicals to activate mitogen activated protein kinase pathway and the ability of collagenases to form minimizing damage to collagen. It also decreases damage caused by lipid peroxidases to li[pids, proteins and DNA.
Hyaluronic Acid9,10
Hyaluronic acid is thought to work through two mechanisms 1) as a passive structural molecule and 2) as a signaling molecule (based on its molecular size). Hyaluronic acid has hydgroscopicity and viscoelasticity properties. It is highly anionic that can attract water. This attraction of water provides the ability of the skin to create volume and provide structural support. The signaling mechanism may be facilitated by its anti-inflammatory properties through its effects on cell migration and cell division.
Lipoic Acid11,12
There are two forms of alpha-lipoic acid. Oxidized lipoic acid and reduced dihydrolipoic acid both act as scavengers of reactive oxidized species. Dihydrolipoic is neutralizes free radicals. It also regenerates vitamins C and E and increases glutathione synthesis.
Common1-12
Contraindications1-12
Precautions1-12
Store at 20°C to 25°C (68°F to 77°F) in a dry place, away from heat and light. Keep out of reach of children.
WPPL operates as a 503A compounding pharmacy and prepares individualized prescription medications pursuant to provider direction. Compounded preparations are not reviewed, tested, or approved by the FDA.
This listing also includes commercially manufactured products for convenience; these items are not compounded by our pharmacy and are sold as provided by their manufacturers. Actual products in stock at time of dispensing may vary due to supply chain variability. Any statements regarding non-compounded products are manufacturer-supplied, have not been evaluated by the FDA, and are not intended to diagnose, treat, cure, or prevent any disease. WPPL does not verify or endorse any therapeutic claims made by manufacturers. Please refer to original labeling for complete product information.
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If you are a physician, clinic, or practice seeking a dependable Compounding Pharmacy partner, WP Pharma Labs is here to help. With dedicated account setup, streamlined ordering and responsive service, we support your therapeutic goals with specialized compounds designed for your patients.
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