Gel
2% / 3%
Product Overview
This topical gel contains sildenafil and arginine. It is formulated to potentially enhance genital blood flow in individuals experiencing erectile dysfunction or female sexual arousal disorder.
Sildenafil1-5
Sildenafil is a phosphodiesterase type 5 (PDE5) inhibitor with a half-life of approximately 4 hours. Clinically, it is used for the treatment of erectile dysfunction and pulmonary hypertension. Research suggests it may also be beneficial for female sexual arousal disorder. Due to its half-life, oral sildenafil is typically used “on-demand” prior to sexual activity.
Arginine6,7
L-Arginine is an essential amino acid that is converted in the body to nitric oxide, a potent vasodilator and neurotransmitter. It is naturally present in foods such as red meat, poultry, fish, and dairy. Arginine also supports protein synthesis, immune function, and wound healing.
Sildenafil1-4
Phosphodiesterase (PDE) has many isoforms and is an enzyme that has many functions in the body including degrading the effect of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). PDE5 is an enzyme that is found in many parts of the body including in the smooth muscle of the corpus cavernosum, prostate, bladder, the vascular and visceral smooth muscle, skeletal muscle, urethra, platelets, kidney, lung, cerebellum, heart, liver, testis, seminal vesicle, and pancreas. Sildenafil is structurally similar to cGMP and prevents degradation of cGMP by competitively binding and inhibiting activity of PDE5. When PDE5 is inhibited, cGMP accumulates and leads to smooth muscle relaxation. Studies have shown that sildenafil facilitates the relaxation of the clitoral corpus cavernosum through the nitric oxide-cGMP pathway. This may improve genital blood flow and vaginal engorgement.
Arginine6,7
L-Arginine is necessary for making proteins and is commonly used to promote circulation. The body converts arginine to nitric oxide (NO) through the action of nitric oxide synthase which may relax blood vessels, allowing more blood to flow.
Common (topically)1-7
Oral (sildenafil)1-3
Contraindications1-7
Precautions1-7
Store at 20–25°C (68–77°F). Protect from excessive heat, light, and moisture.
WPPL operates as a 503A compounding pharmacy and prepares individualized prescription medications pursuant to provider direction. Compounded preparations are not reviewed, tested, or approved by the FDA.
This listing also includes commercially manufactured products for convenience; these items are not compounded by our pharmacy and are sold as provided by their manufacturers. Actual products in stock at time of dispensing may vary due to supply chain variability. Any statements regarding non-compounded products are manufacturer-supplied, have not been evaluated by the FDA, and are not intended to diagnose, treat, cure, or prevent any disease. WPPL does not verify or endorse any therapeutic claims made by manufacturers. Please refer to original labeling for complete product information.
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