(Navra-Gel Moderate) Facial Gel
5% / 0.05%
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Product Overview
This is a compounded skincare formulation containing niacinamide and tretinoin, designed to support the appearance of healthy skin. These ingredients are commonly included to help reduce visible signs of aging, promote a more even complexion, and address areas of pigmentation.
Niacinamide1-3
Niacinamide, a form of vitamin B3, is a water-soluble nutrient important for cellular metabolism. While niacin and niacinamide are both forms of vitamin B3, they differ slightly in structure. Niacinamide is recognized for its soothing properties and may assist in calming irritation while supporting the skin barrier. When applied topically, it may be considered for use in conditions such as acne vulgaris, melasma, psoriasis, and signs of aging.
Tretinoin4,5
Tretinoin, a naturally occurring derivative of vitamin A, is also known as all-trans-retinoic acid. Retinoids can influence cell reproduction, proliferation, and differentiation. Tretinoin is used under professional guidance as part of customized treatment plans for acne vulgaris and photoaging, including facial wrinkles, skin roughness, and areas of pigmentation. For pigmentation concerns, tretinoin may help regulate the enzyme tyrosinase, which plays a role in melanin production.
References
Niacinamide1-3
Niacinamide has various mechanisms of activity to support skin health. Niacinamide is a precursor to the NAD(P) family of coenzymes. These coenzymes are important for metabolic activity in the skin. The reduced form, NAD(P)H, has antioxidant activity and works to neutralize free radicals. Niacinamide provides anti-inflammatory activity and decreases sebum excretion. It has been studied for acne vulgaris by affecting neutrophil chemotaxis and suppresses cytokine-mediated induction of nitric oxide synthase. In addition, niacinamide has been studied for its role in prevention of photoimmunosuppression and photocarcinogenesis, loss of collagen in the dermal layer of skin, and improvement in the barrier function of the skin. Niacinamide has been studied for its support of increasing collagen production reducing the amount of dermal glycosaminoglycans that are seen with photodamaged or wrinkled skin. Niacinamide may support the barrier function of the skin by increasing the lipid and protein stratum corneum. This increase in lipid and protein decreases the trans-epidermal water loss and provides resistance to skin damage from damaging agents. Niacinamide also is thought to inhibit the transfer of melanin from the melanocytes to keratinocytes to decrease hyperpigmentation of skin.
Tretinoin4,5
Tretinoin binds to retinoic acid receptors (RARs) alpha, beta, and gamma along with retinoid X receptors (RXRs) to block inflammatory mediators. In addition, during the binding to the retinoid acid receptor, the production of procollagen increases to augment collagen type I and III formations.
Niacinamide1-3,6
Common
Tretinoin:4,5
Common
Contraindications1-6
Precautions1-6
Store at 20–25°C (68–77°F), in a cool, dry place, away from heat and direct sunlight. Do not freeze. Keep container tightly closed and out of reach of children.
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