Gonadorelin

Injection

1 mg Vial  |  2 mg Vial

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Disclaimer: Images are for reference only; actual products may vary.

Product Overview

Gonadorelin Description1-5

Gonadorelin is a synthetic decapeptide that shares the identical amino acid sequence with naturally occurring gonadotropin-releasing hormone (GnRH). Both consist of 10 amino acids arranged in the sequence pyro-Glu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH₂.

Clinically, gonadorelin is used as a diagnostic agent following pituitary surgery. In males, follicle-stimulating hormone (FSH) and luteinizing hormone (LH) stimulate testosterone and sperm production. In females, FSH and LH are involved in regulation of the menstrual cycle and ovulation. Gonadorelin has a half-life ranging from approximately 2 to 40 minutes.

Mechanism of Action1-5

GnRH is made in the hypothalamus and functions to stimulate the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary. This increase in FSH and LH may stimulate the production and release of testosterone by the male testes and estrogen by the female ovaries and placenta.

Common1-5

  • Headache
  • Nausea
  • Abdominal discomfort
  • Flushing
  • Dizziness or lightheadedness
  • Injection site reactions such as redness, pain, or swelling

Contraindications1,2,4

  • Intolerance or hypersensitivity to gonadorelin
  • Use in pregnant or breastfeeding women is contraindicated

Precautions1,2,4

  • Rare instances of hypersensitivity reaction (bronchospasm, tachycardia, flushing, urticaria, induration at injection site) and anaphylactic reactions have been reported following multiple-dose administration.
  • There has been a report of pituitary apoplexy and sudden blindness following gonadotropin-releasing hormone administration to a patient with a gonadotropin-secreting adenoma.

Store refrigerated at 36°F to 46°F (2°C – 8°C). Discard 28 days after mixing. Do not freeze. Keep out of reach of children and pets.

  1. DrugBank. Gonadorelin: Uses, Interactions, Mechanism of Action.
    https://go.drugbank.com/drugs/DB00644 
  2. RxList. Factrel (Gonadorelin): Side Effects, Uses, Dosage https://www.rxlist.com/factrel-drug.htm#description. August 8, 2022
  3. Medicines.org.uk. Gonadorelin 100 mcg Powder for Solution for Injection – SmPC.
    https://www.medicines.org.uk/emc/product/4853/smpc 
  4. DailyMed. GONABREED – Gonadorelin Injection, Solution.
    https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=9bc44a48-ff45-468a-a60d-c490a667
  5. Gonadorelin’s Potential Interactions With The Hypothalamic-Pituitary-Gonadal Axis https://www.corepeptides.com/gonadorelins-potential-interactions-with-the-hypothalamic-pituitary-gonadal-axis/ June 7, 2025 Accessed July 14, 2025

WPPL operates as a 503A compounding pharmacy and prepares individualized prescription medications pursuant to provider direction. Compounded preparations are not reviewed, tested, or approved by the FDA.

This listing also includes commercially manufactured products for convenience; these items are not compounded by our pharmacy and are sold as provided by their manufacturers. Actual products in stock at time of dispensing may vary due to supply chain variability. Any statements regarding non-compounded products are manufacturer-supplied, have not been evaluated by the FDA, and are not intended to diagnose, treat, cure, or prevent any disease. WPPL does not verify or endorse any therapeutic claims made by manufacturers. Please refer to original labeling for complete product information.

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