GHK-Cu / Hyaluronic Acid

(Clinical Strength) Gel

0.055% / 0.5%

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Disclaimer: Images are for reference only; actual products may vary.

Product Overview

GHK-Cu Description1

GHK-Cu is a naturally occurring copper-binding peptide involved in tissue remodeling and repair. It consists of a tripeptide (glycine–histidine–lysine) bound to copper (II). It is endogenously present in human plasma, and its levels decrease with age.

Topical formulations containing GHK-Cu are used for their potential role in supporting skin regeneration, enhancing skin appearance, and supporting scalp health. Some evidence also suggests that the peptide may have an effect on hair follicle growth.

Hyaluronic Acid Description2,3 

Hyaluronic acid is a glycosaminoglycan that plays an important role in the skin. It contributes to hydration, elasticity, and overall skin integrity, and it is also involved in wound healing. With aging, hyaluronic acid production declines, which is associated with drier skin and reduced elasticity.

GHK-Cu1

The activity of GHK-Cu is thought to be multifaceted and includes:

  1. Gene Modulation:

GHK-Cu has been associated with the upregulation of genes involved in tissue repair, anti-inflammatory signaling, and antioxidant defense, and the downregulation of genes linked to fibrosis and oxidative stress.

  1. Skin Health Support:

Evidence suggests GHK-Cu may enhance dermal fibroblast function, collagen synthesis, and extracellular matrix remodeling—factors that contribute to skin firmness, elasticity, and texture.

  1. Hair Follicle Environment:

GHK-Cu may modulate the follicular microenvironment through support of cell proliferation and anti-inflammatory effects. Preclinical studies have proposed its influence on hair follicle cycling and dermal papilla cell activity.

 

Hyaluronic Acid2,3

Hyaluronic acid may have the following two mechanisms for its activity on the skin: 1) as a passive structural molecule and 2) as a signaling molecule (based on its molecular size). Hyaluronic acid has hydgroscopicity and viscoelasticity properties. It is highly anionic that can attract water. This attraction of water provides the ability of the skin to create volume and provide structural support. The signaling mechanism may be facilitated by its anti-inflammatory properties through its effects on cell migration and cell division.

GHK-Cu1

Common

Mild local irritation

  • Sensitivity to other ingredients when combined in multi-agent products
  • Discoloration or staining

Hyaluronic Acid4

Common

  • Irritation, redness, and itchiness.

Contraindications1-4

  • Hypersensitivity to GHK, copper peptides, hyaluronic acid or excipients
  • Active local infection, open wounds, or compromised skin barrier at site of application

Precautions1-4

  • Avoid contact with mucous membranes and eyes

Store at 2°C–8°C (36°F–46°F). Protect from light, heat, and moisture.

  1. Pickart L, Margolina A. Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data. Int J Mol Sci. 2018;19(7):1987. doi:10.3390/ijms19071987 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073405/
  2. Fallacara A, Baldini E, Manfredini S, Vertuani S. Hyaluronic Acid in the Third Millennium. Polymers (Basel). 2018 Jun 25;10(7):701.
  3. Bravo B, Correia P, Gonçalves Junior JE, Sant’Anna B, Kerob D. Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to clinical evidence. Dermatol Ther. 2022 Dec;35(12):e15903.
  4. Modglin L, Cho J. Hyaluronic Acid: Benefits, Uses And More – Forbes Health. January 4, 2024. https://www.forbes.com/health/supplements/hyaluronic-acid/ Accessed August 25, 2025.

WPPL operates as a 503A compounding pharmacy and prepares individualized prescription medications pursuant to provider direction. Compounded preparations are not reviewed, tested, or approved by the FDA.

This listing also includes commercially manufactured products for convenience; these items are not compounded by our pharmacy and are sold as provided by their manufacturers. Actual products in stock at time of dispensing may vary due to supply chain variability. Any statements regarding non-compounded products are manufacturer-supplied, have not been evaluated by the FDA, and are not intended to diagnose, treat, cure, or prevent any disease. WPPL does not verify or endorse any therapeutic claims made by manufacturers. Please refer to original labeling for complete product information.

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