Chewable Tablet
55 mg / 20 mg / 125 U
Product Overview
Sildenafil Description1-3
Sildenafil is a phosphodiesterase type 5 (PDE5) inhibitor with a half-life of about 4 hours. Clinically, it is used for erectile dysfunction and pulmonary hypertension. Due to its half-life, sildenafil is typically taken “on-demand” before sexual activity.
Tadalafil Description4-6
Tadalafil, also a phosphodiesterase type 5 (PDE5) inhibitor, has a mean terminal half-life exceeding 17 hours, significantly longer than other medications in this class. This prolonged half-life supports both once-daily use and on-demand dosing. Tadalafil is indicated for pulmonary arterial hypertension (PAH), erectile dysfunction (ED), benign prostatic hypertrophy (BPH), and for patients requiring treatment for both ED and BPH simultaneously.
Oxytocin Description7-12
Oxytocin is a hormone produced in the hypothalamus and stored in the posterior pituitary gland. A synthetic form is available and functions the same as naturally occurring oxytocin. It stimulates smooth muscle contractions in the uterus during labor and promotes milk ejection through its action on the alveolar ducts after milk is formed. Because of these uterine effects, oxytocin has been used for labor induction, assistance with placental delivery, and management of postpartum bleeding. Oxytocin has also been linked to social bonding, mood-related effects, and aspects of sexual function.
Sildenafil1-3
Phosphodiesterase (PDE) has many isoforms and is an enzyme that has many functions in the body including degrading the effect of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). PDE5 is an enzyme that is found in many parts of the body including in the smooth muscle of the corpus cavernosum, prostate, bladder, the vascular and visceral smooth muscle, skeletal muscle, urethra, platelets, kidney, lung, cerebellum, heart, liver, testis, seminal vesicle, and pancreas. Sildenafil is structurally similar to cGMP and prevents degradation of cGMP by competitively binding and inhibiting activity of PDE5. When PDE5 is inhibited, cGMP accumulates and leads to smooth muscle relaxation. In the corpus cavernosum, this leads to penile erection. In the pulmonary system, it leads to vasodilation in the pulmonary arteries.
Tadalafil4-6
Phosphodiesterase (PDE) has many isoforms and is an enzyme that has many functions in the body including degrading the effect of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). PDE5 is an enzyme that is found in many parts of the body including in the smooth muscle of the corpus cavernosum, prostate, bladder, the vascular and visceral smooth muscle, skeletal muscle, urethra, platelets, kidney, lung, cerebellum, heart, liver, testis, seminal vesicle, and pancreas. Tadalafil is a selective inhibitor of PDE5, the enzyme responsible for the degradation of cGMP. The drug has selective activity on PDE5 than other phosphodiesterase isoforms. Tadalafil activity on PDE5 is more than 10,000-fold more than for PDE1, PDE2, PDE4, and PDE7 enzymes. Increased cGMP leads to smooth muscle relaxation in the corpus cavernosum which can help in maintaining an erection.
Oxytocin7-12
Oxytocin causes G-protein coupled receptors to increase intracellular calcium which leads to uterine contraction. The stimulation of uterine contractions causes more oxytocin to be released. As more oxytocin is released it positively influences even more release of oxytocin. This release of oxytocin is called positive feedback which is much different than how many hormones work in the endocrine system. Oxytocin administered exogenously causes the same response as endogenously produced oxytocin. Not only does oxytocin stimulate uterine contractions, but it also causes contractions of myoepithelial cells in the alveolar ducts found in female breast tissue. These contractions force milk from these ducts into even larger sinuses, which subsequently enables milk expulsion. When a baby attempts to latch onto the mother’s breast it causes oxytocin secretion into the blood in the same manner as vaginal delivery; instead of uterine contractions, milk is ejected from the breast. Similar to the actions of oxytocin in the uterus to stimulate contractions during delivery, milk-ejection from breast tissue occurs due to positive feedback. In the brain, it is proposed that oxytocin stimulates social and sexual function by its activity in many areas of the brain including its activity on neurotransmitters.
Sildenafil1,2
Common
Tadalafil4,5
Common
Oxytocin7-9
Common
Contraindications & Precautions1,2,4,5,7-9
Sildenafil
Contraindications:
Precautions:
Tadalafil
Contraindications
Precautions
Oxytocin
Contraindications
Precautions
WPPL operates as a 503A compounding pharmacy and prepares individualized prescription medications pursuant to provider direction. Compounded preparations are not reviewed, tested, or approved by the FDA.
This listing also includes commercially manufactured products for convenience; these items are not compounded by our pharmacy and are sold as provided by their manufacturers. Any statements regarding non-compounded products are manufacturer-supplied, have not been evaluated by the FDA, and are not intended to diagnose, treat, cure, or prevent any disease. WPPL does not verify or endorse any therapeutic claims made by manufacturers. Please refer to original labeling for complete product information.
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