Capsule
1.5 mg | 3 mg | 4.5 mg
Product Overview
Naltrexone (LDN) Description1-5
Low Dose Naltrexone (LDN) refers to naltrexone hydrochloride administered in doses ranging from 0.5 mg to 4.5 mg, which is substantially lower than the standard 50–100 mg doses used for opioid or alcohol dependence. At these lower doses, naltrexone may have immunomodulatory and anti-inflammatory effects and can be compounded into capsules.
Under the supervision of a healthcare provider, LDN may be considered as an adjunct for conditions such as:
Mechanism of Action1-5
There are several potential pathways that may explain the activity of low-dose naltrexone, although further studies are needed to fully understand the mechanism of action. The following are potential pathways of activity:
LDN may temporarily block opioid receptors (especially μ-opioid receptors) for a few hours.
This transient blockade can lead to a rebound increase in endogenous endorphins and enkephalins when the drug is cleared.
Higher levels of endorphins may enhance immune system regulation and reduce pain perception.
Naltrexone acts as a non-specific antagonist of TLR4, found on microglia in the CNS.
By inhibiting TLR4, LDN reduces the release of pro-inflammatory cytokines (e.g., TNF-α, IL-6).
This may help to reduce neuroinflammation, often implicated in chronic pain and autoimmune disorders.
LDN is thought to restore T-regulatory cell function and normalize Th1/Th2 balance, critical in autoimmune disease regulation.
May inhibit abnormal B-cell activity and reduce autoantibody production.
Common1-5
Contraindications1-5
Precautions1-5
WPPL operates as a 503A compounding pharmacy and prepares individualized prescription medications pursuant to provider direction. Compounded preparations are not reviewed, tested, or approved by the FDA.
This listing also includes commercially manufactured products for convenience; these items are not compounded by our pharmacy and are sold as provided by their manufacturers. Actual products in stock at time of dispensing may vary due to supply chain variability. Any statements regarding non-compounded products are manufacturer-supplied, have not been evaluated by the FDA, and are not intended to diagnose, treat, cure, or prevent any disease. WPPL does not verify or endorse any therapeutic claims made by manufacturers. Please refer to original labeling for complete product information.
EXPLORE MORE
Related Medications
Licensed to ship across the U.S.
Your orders arrive promptly and privately, delivered directly to your door.
Providers: Let’s Partner for Better Patient Care
If you are a physician, clinic, or practice seeking a dependable Compounding Pharmacy partner, WP Pharma Labs is here to help. With dedicated account setup, streamlined ordering and responsive service, we support your therapeutic goals with specialized compounds designed for your patients.
To check product availability, check on the status of an existing order, request refills:
orders@wppharmalabs.com
New providers setup / update an existing account:
newaccounts@wppharmalabs.com
