Capsule
22 mg / 0.25 mg | 45 mg / 0.25 mg
Product Overview
Clomiphene (Clomid™) Description1,2,3
Clomiphene, originally marketed as Clomid™, is a fertility medication used to induce ovulation in women who ovulate infrequently or not at all. It stimulates ovulation in patients with an intact hypothalamic-pituitary-ovarian axis and normally functioning ovaries. In women, clomiphene promotes the release of pituitary gonadotropins, initiating steroidogenesis and folliculogenesis, which leads to ovarian follicle development and increased circulating estradiol levels. In men with low testosterone, the drug can increase testosterone levels through stimulation of LH and FSH production.
Anastrozole Description4
Anastrozole is a selective non-steroidal aromatase inhibitor. It is used in postmenopausal women with hormone receptor-positive breast cancer.
Clomiphene Mechanism of Action1,2,3
Clomiphene is classified as a selective-estrogen receptor-modulator due to its ability to compete with estradiol for estrogen receptors at the level of the hypothalamus. The drug blocks the normal negative feedback of circulating estradiol on the hypothalamus, preventing estrogen from lowering the output of gonadotropin releasing hormone. Gonadotropin releasing hormone pulses increases during clomiphene therapy and stimulates the pituitary gland to release more FSH and LH. For women, FSH and LH stimulate the ovaries to develop oocyte follicles. For men, it stimulates the production of testosterone.
Anastrozole Mechanism of Action4,5,6
In postmenopausal women, estrogens are mainly derived from the action of the aromatase enzyme, which converts adrenal androgens (primarily androstenedione and testosterone) to estrone and estradiol. Suppression of estrogen biosynthesis in peripheral tissues and in cancer cells can be achieved by specifically inhibiting the aromatase enzyme. Therapeutically, this inhibition results in decreased systemic estrogen levels and increased systemic testosterone levels, which is therapeutic in estrogen-dependent breast cancers and in disease states where increased testosterone is important.
Clomiphene Adverse Reactions1,2
Anastrozole Adverse Reactions4
Common
Clomiphene Contraindications & Precautions1,2
Contraindications
Precautions
Anastrozole Contraindications & Precautions4,6
Contraindications
Precautions:
WPPL operates as a 503A compounding pharmacy and prepares individualized prescription medications pursuant to provider direction. Compounded preparations are not reviewed, tested, or approved by the FDA.
This listing also includes commercially manufactured products for convenience; these items are not compounded by our pharmacy and are sold as provided by their manufacturers. Actual products in stock at time of dispensing may vary due to supply chain variability. Any statements regarding non-compounded products are manufacturer-supplied, have not been evaluated by the FDA, and are not intended to diagnose, treat, cure, or prevent any disease. WPPL does not verify or endorse any therapeutic claims made by manufacturers. Please refer to original labeling for complete product information.
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Related Medications
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Providers: Let’s Partner for Better Patient Care
If you are a physician, clinic, or practice seeking a dependable Compounding Pharmacy partner, WP Pharma Labs is here to help. With dedicated account setup, streamlined ordering and responsive service, we support your therapeutic goals with specialized compounds designed for your patients.
To check product availability, check on the status of an existing order, request refills:
orders@wppharmalabs.com
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newaccounts@wppharmalabs.com
